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(Anatomy) (Phys) Ultrasound's New Focus

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PostPosted: Mon May 01, 2006 10:44 am    Post subject: (Anatomy) (Phys) Ultrasound's New Focus Reply with quote

Science News Online
Week of April 29, 2006; Vol. 169, No. 17

Ultrasound's New Focus
Can it eradicate tumors?
Ben Harder

The Dominican Republic is known among tourists for its white sands, magnificent waterfalls, and unusual wildlife. But none of those was the attraction that drew Charles A. Reinwald. He came for a rendezvous with an ultrasound device. Reinwald had aggressive prostate cancer, and he didn't care for the treatment options available in the United States. So, one day in late June 2004, Reinwald traveled from his home in Tequesta, Fla., to a hospital in the Dominican city of Santiago. There, a Miami-based urologist directed ultrasonic waves at the patient's cancerous prostate gland.

The Dominican Republic and various other countries, including Canada, England, and Mexico, permit doctors to treat prostate cancer with a technique called high-intensity focused ultrasound, or HIFU. It often avoids the irreversible side effects, including impotence, that can arise during surgery, radiation, and the other treatments available in the United States.

In the Santiago hospital, urologist George Suarez and his assistants inserted a transducer emitting ultrasonic waves into Reinwald's rectum. The curved transducer put the waves on converging paths in the same way that a magnifying glass focuses sunlight. Where the streams of energy intersected at the prostate, the temperature soared to more than 80°C, cooking small batches of tumor cells in seconds.

For about 2 hours, the transducer steadily shifted its aim across rows of space. Its progress resembled that of a dot matrix printer applying ink to paper. Tissue just millimeters away from the HIFU target zone remained unharmed.

Reinwald's cancer isn't cured, but he hasn't required medical intervention since the operation. At age 80, he works full-time as president of the Cancer Cure Coalition, a nonprofit organization that he founded in 2000 after his wife's diagnosis of cancer.

He expresses no regrets about his HIFU treatment. "Why do [surgery] when I have available to me a less toxic treatment?" he asks.

HIFU, however, is not generally available in the United States. It has been approved for only one use: treating uterine fibroids. Suarez and other urologists who treat U.S. men who have prostate cancer do so abroad and charge about $20,000 per case. Patients also need to pay their own way to Santiago, Toronto, or another foreign city to undergo the procedure.

A handful of companies market HIFU devices. Although they vary in design and therapeutic purpose, all the machines rely on the same underlying principle. They focus ultrasound energy at a point several centimeters away from the transducer and destroy tissue there.

The companies, including US HIFU of Charlotte, N.C., which Suarez partially owns, have funded research to test whether the new approach is safer and more effective for a variety of cancers than standard therapies are. Breast, bone, brain, and liver tumors are among those cancers being treated experimentally with HIFU. Investigators also continue to study the efficacy of the technique in women with fibroids. In each case, physicians must place the transducer within a few centimeters of the target.

While HIFU appears to sidestep some typical side effects of surgery and radiation, it's not yet clear whether the novel approach is as successful at curing cancers as those standard treatments are. So far, no study has directly compared the ultrasound procedure to an established cancer treatment.

A British government body, the National Institute for Clinical Excellence, maintains that the evidence "appears adequate to support the use of this procedure for prostate cancer." But it also states in a document that offers guidance to the National Health Service, "The effects of HIFU for prostate cancer on quality of life and long-term survival remain uncertain."

Fixing fibroids
Uterine fibroids are nonmalignant tumors that can impair fertility and sometimes cause pain, heavy menstrual bleeding, and urinary frequency. The condition has traditionally been treated by surgical removal of the uterus, or hysterectomy. This approach definitively rids a woman of fibroids and relieves the pressure that the fibroids had placed on nearby tissues.

In contrast, HIFU "does not totally get rid of the fibroids," says radiologist Fiona Fennessy of Brigham and Women's Hospital in Boston. "This isn't a malignant tumor. All we're trying to do is improve symptoms."

To minimize risks such as skin burns and damage to healthy internal tissues, radiologists destroy only the center of the fibroid and don't attempt to heat the surrounding area, called the margin, Fennessy says.

However, because the blood vessels that support a fibroid are concentrated near its core, destroying the center usually eliminates part of the margin, says gynecologist Phyllis Gee, director of the North Texas Uterine Fibroid Institute in Plano.

To evaluate HIFU's success, Brigham and Women's researchers led by gynecologist Elizabeth A. Stewart treated more than 100 women who had fibroids. The team used a machine made by InSightec Ltd. of Haifa, Israel, that incorporates an ultrasound transducer into a magnetic-resonance (MR) scanner.

During treatment, a sedated woman lies facedown on the bed of the scanner. Beneath her abdomen, the ultrasound transducer aims and fires away for up to 3 hours while the MR scanner lets doctors monitor tissue temperature and fibroid position.

Most patients experience a "mild level of pain" during and immediately after procedure, Stewart says.

Stewart's team reported in the January Fertility and Sterility that 71 percent of the patients treated have a significant reduction in fibroid symptoms for at least 6 months, and 51 percent experience that improvement for at least a year. HIFU doesn't produce sufficient relief for all women, however. Seventeen percent of the volunteers sought another treatment, such as hysterectomy, within a year, Stewart says.

Women treated with HIFU missed an average of 1.4 days of work after the operation, Stewart says. That compares with 18.9 missed days among women treated by hysterectomy for similar fibroids, Stewart reported in Jerusalem last June to the Israel Society of Obstetrics and Gynecology.

To measure the benefit 3 years after treatment, Gee is leading a new study that will track 70 women with fibroids who received HIFU. InSightec funded both studies.

After reviewing preliminary clinical data, the U.S. Food and Drug Administration in late 2004 approved the InSightec equipment for clinical use in treating fibroids.

Sounding out malignancies
Unlike fibroids, malignant tumors need to be rooted out entirely if they're to be beaten. In surgery, doctors remove a specific amount of surrounding healthy tissue to avoid leaving behind any cancer cells. Similarly, in HIFU, doctors may need to kill a veneer of healthy tissue around each tumor, concluded Moshe Papa and Douglas Zippel of Sheba Medical Center in Tel Hashomer, Israel, in the January 2005 Breast Cancer.

Those researchers used HIFU to treat 10 women who had breast cancer and were planning to have partial mastectomies. After the procedure, the investigators removed a portion of each treated breast to see whether HIFU had eliminated the tumors. Two volunteers showed no sign of remaining cancer, but eight patients retained at least some cancerous cells at the tumor site.

Feng Wu and his colleagues in Chongqing, China, have taken a more aggressive approach. Between 1998 and 2001, they administered HIFU—in combination with either surgery or chemotherapy—to 45 women with breast cancer. They intentionally destroyed a 1.5-to-2-centimeter-thick layer of normal tissue around each tumor.

Five years later, 89 percent of the women had had no recurrence of disease, Wu reported last December at the Radiological Society of North America meeting in Chicago. Wu holds stock in the company that makes the device that his team tested. The study didn't include a comparison group of similar patients receiving a conventional treatment.

In other studies, it's not uncommon to find that after surgery and radiation therapy, more than 90 percent of volunteers who have breast cancer go at least 5 years without recurrence.

InSightec-sponsored researchers have begun a trial of HIFU in treating breast tumors and surrounding breast tissue in 200 women in Germany and Japan.

The cosmetic side effects of HIFU are minimal. Since HIFU doesn't break the skin, it rarely disfigures the breast, Wu says.

David Gianfelice of Toronto General Hospital, one of the first North American researchers to use HIFU in breast cancer treatment, notes that third-degree skin burns have resulted in some cases. But recent refinements to the InSightec hardware have minimized that problem, he says.

By delivering "a nice, tight package of heat" to the tumor, MR-guided HIFU might eventually supplant surgery as the treatment in some cases of breast cancer, Gianfelice says.

That same goal applies in prostate cancer, which researchers abroad have been treating with HIFU since the mid-1990s. For example, more than 400 men with early-to-mid-stage prostate cancer have received HIFU as an initial therapy using the device manufactured by EDAP of Vaulx-en-Velin, France.

Andreas Blana and his colleagues at the University of Regensburg in Germany reported results from 146 of these patients, who were tracked for an average of nearly 2 years. Blana's team reported in the February 2004 Urology that 87 percent of the patients remained free of their cancer. In studies of traditional prostate cancer therapies, up to 95 percent of men with early-stage cancer remain cancerfree at least 5 years after treatment.

At Hachioji Hospital in Tokyo, Toyoaki Uchida and his colleagues have treated more than 200 men since 1999.

Overall, 81 percent of the men remained free of disease 1 year after the procedure, and 77 percent had no disease after 5 years, Uchida reported at a meeting of the International Society for Therapeutic Ultrasound in Boston last October.

But more evidence is needed to prove that HIFU rids men of cancer as effectively as established therapies do, says urologist Peter Scardino of Memorial Sloan-Kettering Cancer Center in New York City.

Other researchers are now testing HIFU in patients with terminal liver or brain cancer or patients in whom tumors from other organs have spread to bone. These trials are intended to relieve pain.

Just warming up
In addition to scoring direct hits against cancer, HIFU may provide assists when used in combination with established drugs. Researchers at the National Institutes of Health's Clinical Center in Bethesda, Md., showed at last year's radiology meeting that HIFU can boost the amount of a chemotherapy drug that reaches a tumor. Sergio Dromi and his colleagues injected skin tumor–carrying mice with microscopic envelopes of fat, called liposomes, that contained the anticancer drug doxorubicin. Liposomes carry drugs and other substances into cells.

In some mice, the researchers then used a HIFU machine to deliver intermittent pulses of ultrasound energy to each tumor, elevating its temperature to 42°C and breaking down the liposomes. Examination of the tumors revealed that three times as much doxorubicin reached the target in the HIFU-treated mice as in the other mice.

Other researchers are pursuing HIFU as a method for cauterizing hemorrhaging internal wounds ( SN: 1/6/01, p. 12: Available to subscribers at ) and breaking up blood clots and kidney stones ( SN: 11/26/05, p. 346: Available to subscribers at ).

Suarez, the urologist who treated Reinwald in Santiago, anticipates that HIFU may treat pancreatic and kidney cancer, fix heart arrhythmias, and even improve liposuction.

Use of HIFU for cancer could dramatically reduce health care costs, argues Suarez. It requires little or no hospitalization and less recovery time than alternative treatments do. Because HIFU is associated with a low rate of permanent complications, it also decreases the cost of treating those side effects.

"I'm treating about 20 patients a month [with HIFU]," Suarez says. "We are concentrating on prostate cancer right now. There's a sense of urgency—it is the most common cancer in men."


Blana, A., et al. 2004. High-intensity focused ultrasound for the treatment of localized prostate cancer: 5-year experience. Urology 63(February):297-300. Abstract available at

Dromi, S., et al. 2005. Pulsed-high intensity focused ultrasound (HIFU) enhanced delivery of doxorubicin using heat sensitive liposome (Thermodox). Meeting of the Radiological Society of North America. Dec. 1. Chicago. Abstract.

Fennessy, F., . . . E.A. Stewart, et al. 2005. Evaluation of symptom relief and fibroid reduction one year following MR-guided focused ultrasound surgery. Meeting of the Radiological Society of North America. Nov. 28. Chicago. Abstract.

National Institute for Clinical Excellence. 2005. High-intensity focused ultrasound for prostate cancer. Interventional Procedure Guidance 118 (March).

Stewart, E.A., et al. 2006. Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids. Fertility and Sterility 85(January):22-29. Abstract available at

Stewart, E.A. 2005. MR guided focused ultrasound: A fibroid-specific treatment. Meeting of the Israel Society of Obstetrics and Gynecology, June 5: Jerusalem. Available at

Uchida, T., et al. 2006. Treatment of localized prostate cancer using high-intesity focused ultrasound. BJU International 97(January):56-61. Abstract available at

Uchida, T., et al. 2005. Transrectal high-intensity focused ultrasound in the treatment of localized prostate cancer: A multicenter study. Hinyokika Kiyo 51(October):651-658. Abstract.

Uchida, T. 2005. HIFU for localized prostate cancer: 6 year experience. Meeting of the International Society for Therapeutic Ultrasound. Oct. 27-29. Boston.

Wu, F., et al. 2005. Clinical phase II and phase III trials using high intensity focused ultrasound treatment for patients with breast cancer. Meeting of the Radiological Society of North America. Dec. 2. Chicago. Abstract.

______. 2003. A randomized clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localized breast cancer. British Journal of Cancer 89(Dec. 15):2227-2233. Abstract available at

Zippel, D.B., and M.Z. Papa. 2005. The use of MR imaging guided focused ultrasound in breast cancer patients; a preliminary phase one study and review. Breast Cancer 12(January):32-38. Available at

Further Readings:

Greene, K. 2005. Mars or bust! Science News 168(Nov. 26)346-348. Available to subscribers at

Sivitz, L. 2001. Beyond imaging. Science News 159(Jan. 6):12-13. Available to subscribers at


Fiona M. Fennessy
Section of Abdominal Imaging and Intervention
Department of Radiology
Brigham and Women's Hospital
Harvard Medical School
75 Francis Street
Boston, MA 02115

Phyllis Gee
North Texas Uterine Fibroid Institute
PMB 131
6009 W. Parker Road, Suite 149
Plano, TX 75093

Charles A. Reinwald
Cancer Cure Coalition
800 Village Square Crossing, Suite 222
Palm Beach Gardens, FL 33410

Peter Scardino
Department of Urology
Memorial Sloan-Kettering Cancer Center
1275 York Avenue
New York, NY 10021

Elizabeth A. Stewart
Center for Uterine Fibroids
Brigham and Women’s Hospital
Harvard Medical School
75 Francis Street
Boston, MA 02115

From Science News, Vol. 169, No. 17, April 29, 2006, p. 264.

Copyright (c) 2006 Science Service. All rights reserved.

Questiosn to explore further this topic:

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What are obstetric ultrasound scans?

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A short history of ultrasound in obstetrics and gynecology

Ultrasound movies

Scans uncover secrets of the womb

3D ultrasound

Other uses of ultrasound imaging

Are there any risks in ultrasound imaging?

What is Doppler ultrasound?

Using ultrasound against cancer

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PostPosted: Tue Aug 07, 2007 9:54 am    Post subject: High-Intensity Ultrasound May Launch an Attack on Cancer, Wh Reply with quote

High-Intensity Ultrasound May Launch an Attack on Cancer, Wherever it Lurks
Duke Comprehensive Cancer Center
August 6, 2007

An intense form of ultrasound that shakes a tumor until its cells start to leak can trigger an “alarm” that enlists immune defenses against the cancerous invasion, according to a study led by researchers at Duke University's Pratt School of Engineering.

The new findings from animal experiments suggest that once activated by the ultrasound, the immune system might even seek and destroy cancer cells, including those that have spread through the bloodstream to lurk in other parts of the body.

This high-intensity focused ultrasound, or HIFU, is in use or testing in China, Europe and the United States to kill tumors by heating them. But Duke researchers now find that HIFU might work even better if it is first delivered in a manner that just shakes the cells. That shaking ruptures tumor cell membranes, causing them to spill their contents. The toxic spill then alerts the immune system to the cancer threat, leading to the production of tumor-fighting white blood cells.

If the effect seen in mice holds true in human patients, such a treatment could be an important advance in many cancer therapies because of its potential to tackle both primary tumors and metastatic cancers that have spread to other organs -- all without the need for surgery, the research team reported in the Journal of Translational Medicine on Aug. 3 (a “provisional” version appeared online on July 11). The work, done by the engineers in collaboration with cancer immunologists and physicians at the Duke Comprehensive Cancer Center, was supported by the National Institutes of Health.

“In most cancers, what actually ends up killing the patient is the spread of the cancer from its original site to other parts of the body,” said Pei Zhong, an associate professor in Duke’s mechanical engineering and materials science department. “If the patient has a tumor in the kidney or liver, several treatment options -- including surgery, radiation or HIFU -- can be used to get rid of the cancerous tissues. However, if the cancer cells spread to other vital organs such as the lung or brain, the outcomes are often much worse.

“HIFU in the current form can only be used to treat the primary tumor,” he continued. “We now think that HIFU delivered in a different mode, with emphasis on using mechanical vibration to break apart the tumor cells, may have an even more significant impact in suppressing cancer metastasis by waking up the immune system.”

For reasons that are still not completely understood, cancer cells often go largely undetected by the immune system, Zhong said. For an anti-tumor immune response to be effective, it may need to recognize not only the surface proteins of cancer cells, but some of the other proteins locked inside those cells, which Zhong called “danger signals.”

The researchers found in mice with colon cancer that mechanical HIFU delivered to the animals’ tumors sparked an immune response twice as strong as did thermal HIFU, presumably by releasing a much more diverse range of danger signals.

“Our results show that while mechanical HIFU is not as effective as thermal HIFU in killing tumor cells directly, it has the potential to induce a stronger anti-tumor immune response,” Zhong said. “These preliminary findings open up the possibility that we could use heat from HIFU to treat the primary tumor and HIFU-boosted immunotherapy for combating any residual and metastatic tumor cells.”

The lead author of this study is Zhenlin Hu, a former research associate in Zhong’s lab who is now at the Second Military Medical University in Shanghai, China. Other co-authors include: Yunbo Liu, Georgy Sankin and Eric Pua from the Department of Mechanical Engineering and Materials Science at Duke’s Pratt School of Engineering, as well as Xiao Yang, Michael Morse, H. Kim Lyerly and Timothy M. Clay from the Duke Comprehensive Cancer Center.
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